", but this line is troubling " Caffeine metabolism yields paraxanthine as a final product, which represents 72 to 80% of caffeine metabolism. WebMD explains how caffeine is a substance that has a short half life. Hello could someone please explain how this would work. Remember it’s also a nonspecific phosphodiesterase inhibitor so some of the effects from amplifying the effect of adrenaline and dopamine receptors. The first three consist of demethylization of N-3 to form Paraxanthine, N-1 to form Theophylline (vasodilator, increased cerebral and muscular blood flow), ". The half-life of caffeine (the time required to clear half of the dose from your bloodstream) is generally estimated to be around 3-6 hours, but singular studies have suggested that the number may be as low as 2 hours or as high as 12 hours. This is the same as an average cup of brewed coffee. Am I right? As an adult, it meant energy drinks and green tea. Daily caffeine consumption amounts are out of control. https://en.wikipedia.org/wiki/Dose%E2%80%93response_relationship. Caffeine is eliminated through first-order kinetics, and has a half life of ~5 hours (with some individual variability). Be aware that sources of caffeine include coffee, tea, Coke, Pepsi, Dr. Pepper, Mountain Dew, 5-Hour Energy Shot, Monster Energy Drinks. Can) 4.7 out of … As a kid, that meant a liter or two of Dr. Pepper a day. Caffeine metabolism varies among different people, but caffeine’s half-life for most people is in the range of 3-7 hours, so evening or even afternoon caffeine can very easily affect the restfulness of your sleep 8 . I'm less interested in the specific case of caffeine and more just wanting to check if my understanding of bodily biochemistry is sound. Our research team went through all of the best caffeine pills on the market, ranking them in order of their quality. Here’s why you’ll want to: caffeine has a six-hour half-life, which means it takes a full twenty-four hours to work its way out of your system. How long until you drop back down the binding curve to "no buzz" territory? One big consideration that this ignores is biological feedback, eg. A 2012 study found … My decision to give up this holy grail of a.m. beverages wasn't mine initially. I shouldn’t have read all those reply’s. I think your logic is correct, so take it a step further. Kicking a caffeine habit can be incredibly difficult, but it also can be well worth your while. A serving can … You’d expect to see a sharp decline in pathway output after initial caffeine ingestion and a slow return to normal governed by some half life, which may diverge significantly from actual blood [caffeine] half-life as you indicated. Or the next step downstream? In terms of half-life, it should take approximately 5-7 hours for your body to get rid of half of it. I found that caffeine had a 6 hours half-life, meaning that the coffee I had after lunch would still be in my blood for 25% when I went to sleep. attenuation of adenosine signaling in this case. So if you’re not shivering in the summer and borderline hallucinating, you’re probably fine. In healthy adults, the half-life is approximately 5 to 6 hours. So I wonder if there's a dose response curve specific to that physiological effect of caffeine. But I'll leave it since it's a topical typo! Chock Full o’Nuts Heavenly Half Caffeine Ground Coffee, Medium Roast - 100% Premium Coffee Beans - Full-Bodied, Bold Flavor Medium Blend with Half the Caffeine of Original Roast (24 Oz. One reason why green tea is particularly effective at boosting mental and physical acuity without side effects is because of the interaction between caffeine and L-theanine, which work together for more optimal effects than caffeine alone. The average half-life of caffeine—that is, how long it takes for half of an ingested dose to wear off—is about five to six hours in a human body. The half-life of caffeine is 4 – 6 hours and you experience the effects of caffeine for at least 4 hours. In the average adult, the half-life of caffeine is about 5-6 hours. Besides that, I found an article that stated that caffeine can lead to poor concentration, anxiety, increased stress levels, irritability, sleeplessness, rapid heart rate, and stomach ache. Half-life is the amount of time it takes for a quantity of a substance to be reduced to half the original amount. 1)" Caffeine is metabolized into more than 25 metabolites in humans, mainly Paraxanthine, Theobromine, and Theophylline [12] " , 2) " coffee - It has a composition of over 2,000 substances ", 3) Paraxanthine, which is the main metabolite of caffeine, is an even more powerful blocker of these receptors than caffeine [2]. Caffeine is known to have a half-life of 5 hours in adults, whereas in neonates, the half-life of caffeine averages 80 hours; a stark contrast. So I guess a useful approximation is that, if you drink enough coffee to feel a buzz then lets just say you are at the Km or something like that. Caffeine pills average between 100 and 200 milligrams of caffeine per serving. Here’s why you’ll want to: caffeine has a six-hour half-life, which means it takes a full twenty-four hours to work its way out of your system. DynaMAX Enhanced Caffeine is a nootropic supplement from Natrium Health, the sister company of Nootropics Depot. Surely you'd be ready for bed by then, I plan to work out at 10 and sleep around 12, It gets halfed every half time, but remember caffeine is metabolized to other xanthines like paraxanthine which also have half life https://upload.wikimedia.org/wikipedia/commons/thumb/3/32/Caffeine_metabolites.svg/1024px-Caffeine_metabolites.svg.png, i found this paper https://www.hindawi.com/journals/ijvm/2010/834060/. There was also a significant positive caffeine x L-theanine interaction on delayed word recognition reaction time.” (Journal of Biological Psychology, 2008) [3] According to the Reddit Nootropics group “ The combination of L-theanine and caffeine may improve attention more than caffeine … Women taking oral birth control require about twice as long to process caffeine. Check price at AmazonZhou Energy + Focus is our top choice because it combines a high 200 mg dose of caffeine with the mediating and synergistic effects of L-theanine. For much of my life, I needed large amounts of caffeine just to get by. Toxicity often is a result of off-target activity so only reporting the decay of on-target activity isn't going to be helpful. Thanks! A caffeine detox may be needed for many reasons and some of those could include: Caffeine may no longer have the same effects it once had. It takes the average adult 1.5 days to fully eliminate caffeine from their system. Someone who consumes 40 milligrams (mg) of caffeine will have 20 mg remaining in their system after 5 hours. You're not stupid and you are worthy. Caffeine enters the bloodstream through the stomach and small intestine and can have a stimulating effect as soon as 15 minutes after it is consumed. So yes, I think it would be more informative to have a half life describing decay in some interesting functional measurement like heart rate rather than raw caffeine concentration because dose response curves are not linear. Caffeine has a half-life of about 5 hours.. I genetically metabolise caffeine at around 3-5x quicker than most folk, would it still last in my system for 5 hours or would my genetic disposition alter that? Caffeine consumption is leading to health problems. There are five main metabolic pathways which contribute to caffeine metabolism in adults [13, 14]. EDIT: care, not cafe. Press question mark to learn the rest of the keyboard shortcuts. Because of my addiction, I was always twitchy and nervous, and could never sleep well or […] It also depends on the total amount of expressed of adenosine receptors, among probably many other factors. In infants and young children, the half-life is longer than in adults; caffeine’s half-life in a newborn may last 30 hours or more. The most popular chemical. I always hear people say how caffeine lasts a long time in your system, and while that may be true, isn't it much more relevant to report the half-life of caffeine activity in your system? Besides that, I found an article that stated that caffeine can lead to poor concentration, anxiety, increased stress levels, irritability, sleeplessness, rapid heart rate, and stomach ache. You might think using them together is redundant, but … Is this a fair assessment? Dose-response curves are likely to be much more complicated and how the response decays could be even more complicated still, requiring many parameters to adequately characterize. When do effects peak? 3. But knowing ahead of the five-day cleanse that I couldn't have caffeine, I decided to go cold turkey. No need to compare your knowledge base to others'! In healthy adults, the half-life is approximately 5 to 6 hours. In this 10 to 12 day trial, the mean number of days with zero apnea events was 3 in the Caffeine Citrate group and 1.2 in the placebo group. Among elderly individuals (age 65+), ability to metabolize caffeine decreases by 33% compared to adults; from a rate of 1.5 ml/min to 1.0 ml/min. You’re worthy because you want to learn more, you’re applying what you have to learned to what you already know and you’re asking good questions. Oral contraceptives double the time it takes to metabolize caffeine; the half-life ranges from 5 to 10 hours; Pregnancy boosts the half-life of caffeine; caffeine’s half-life is 9 to 11 hours in pregnant women. If I have 42mg caffeine at 5 a.m 85mg caffeine at 7 a.m 163mg caffeine at 9 a.m 25 mg caffeine at 9 p.m What is the concentration of caffeine in my blood at 12 a.m (The start of the next day) Half-life of caffeine for most adults is between 2.5 and 4.5 hours when consumption is limited to less than 10 mg/kg. Caffeine Detox: How to Quit Caffeine and Break the Addiction. It uses the popular caffeine+theanine stack, a novel purine alkaloid called Dynamine, and delayed and extended release caffeine to produce a smooth, all-day energy and focus. If I have 42mg caffeine at 5 a.m 85mg caffeine at 7 a.m 163mg caffeine at 9 a.m 25 mg caffeine at 9 p.m What is the concentration of caffeine in my blood at 12 a.m (The start of the next day). While this is yet to be studied in humans, herbal supplements have popped up on the market containing Rutaecarpine that people can take at their own risk. So if you take in 200 mg of caffeine at 9 am, you'll still have about 100 mg left in your body between 2 and 3 pm. We're all just here to learn my dude. And one Starbucks tall coffee can contain 235 mg of caffeine. I always hear people say how caffeine lasts a long time in your system, and while that may be true, isn't it much more relevant to report the half-life of caffeine activity in your system? It depends on what you're actually interested in. That means that drinking a big cup of coffee containing 200 milligrams of caffeine at 3:00 p.m. will leave about 100 milligrams of that caffeine in your system at 9:00 p.m. Adenosine reception, which is affected by caffeine, is important to sleep, and especially to deep sleep. caffeine is not radioactive, so it does not have a half life. I found that caffeine had a 6 hours half-life, meaning that the coffee I had after lunch would still be in my blood for 25% when I went to sleep. Once in the body, caffeine will persist for several hours: it takes about 6 hours for one half of the caffeine to be eliminated. Sure half the caffeine is gone in 5 hours but also during that time your cells may have adjusted to dampen the effects of your buzz, in addition to the slow loss of caffeine. The half-life of caffeine in pregnant women is often four times longer than it is for non-pregnant women—up to 16 hours. Caffeinated beverages like coffee, tea, and soda can alter estrogen levels. If for example a cup of coffee antagonizes adenosine receptors to 90%, but the Km is such that after one 5 hour half-life the antagonist effect is just 10%, it seems that the absolute amount of caffeine in your system is not all that relevant. Extremely young children are thought to process caffeine almost as slow as neonates, but their clearance time dramatic… Caffeine's biological half-life – the time required for the body to eliminate one-half of a dose – varies widely among individuals according to factors such as pregnancy, other drugs, liver enzyme function level (needed for caffeine metabolism) and age. Why the 9 pm one? What I usually cafe about when considering the duration of caffeine's effect on the body is how it might disrupt my sleep, e.g. This can be particularly problematic for caffeine-naive (non-consumers), caffeine-sensitive (lower dosage threshold), and slow-caffeine-metabolizer (less enzyme activity) populations, for whom … I was trying to explain to someone how bad my tree pollen allergy has been lately and I said “it’s so bad I actually run straight to the Claritin first thing in the morning BEFORE the coffee pot!”. This may be what you mean by "caffeine activity". It's more common to be talking about pharmacokinetic metrics like the half-life in the context of drugs that are much more carefully dosed than caffeine. To stack together, take 200-300 mg of Adrafinil first thing in the morning and either have a cup of coffee or 200 mg of caffeine supplement. Of, like, all the chemicals. Caffeine half Life Hello could someone please explain how this would work. I stream cause I think I'm funny but really I'm not. About the half-life of clearance. Can you explain how you “genetically metabolize caffeine 3-5x quicker than most folk”? There are so many intermediate steps that it is easier to ignore them when doing dosing studies. Press question mark to learn the rest of the keyboard shortcuts, https://upload.wikimedia.org/wikipedia/commons/thumb/3/32/Caffeine_metabolites.svg/1024px-Caffeine_metabolites.svg.png, https://www.hindawi.com/journals/ijvm/2010/834060/. I’m not sure if work like this has been done but maybe worth looking for. Age: The speed and efficiency of caffeine clearance tends to increase with age, reaching a peak in adulthood. So, essentially, your day old coffee has still all its caffeine in it, although probably it does not taste that well, but that's caffeine unrelated. This depends purely on how much you intake. 1 Of 85 patients who received drug, 3 were not included in the efficacy analysis because they had <6 apnea episodes/24 hours at baseline.. Keep going downstream until you get to a physiological response you actually care about (eg heart rate, reaction time) and you end up with a "dose response curve". Intimidated by the number of options? Caffeine is one of the most reliable and effective ways to perform better and stay alert during the day or into the night.. Caffeine pills are great if you need a precise dose of caffeine for mental acuity or physical strength and endurance.. if I drink it too late in the day. Furthermore, caffeine readily enters the bloodstream of the fetus, and the fetus has very, very little CYP1A2 activity. Women between the ovulation and beginning of menstruation see a similar, if less severe, extended half-life. Take note of your body’s response When taking caffeine pills, periodically measure your pulse, as it should be <86 bpm. Press J to jump to the feed. Additionally, the clearance of many foreign molecules from the bloodstream is well modeled by exponential decay and thus can be described by a single parameter (either the half life or the rate constant). New comments cannot be posted and votes cannot be cast, More posts from the Biochemistry community, Press J to jump to the feed. This means that once take a dose of caffeine, you'll break down about half of that caffeine after 5-6 hours. Women may especially benefit from going caffeine-free. By mixing caffeine and adrafinil you can experience similar or better results. sorry a bit sidetrackey but your post interested me. And there are a lot of chemicals. Very good point. However, during neonatal development, half-life for the fetus is significantly longer and decreases exponentially after birth to reach a normal rate at about 6 months. twitch.tv/katee_bear Half sane, nerdy, caffeine dependent life-form 31 pan introvert - gamer - otaku I love anything that's a miniature version of itself, magic is real and so is climate change. #23 - Matthew Walker Ph.D - Author of "Why We Sleep: Unlocking the Power of Sleep and Dreams" However, just because caffeine has been cleared from a person’s system doesn’t mean its metabolites (paraxanthine, theobromine, theophylline) will have been eliminated. I’m not worthy to be in this conversation. 25% longer half-life and 30% slower absorption rate which led to 45% more caffeine in the bloodstream after 4 hours and 51% more caffeine in the bloodstream after 6 hours At 6 hours participants showed less fatigue, greater concentration, alertness, energy, and focus compared to both baseline and traditional caffeine users Half-lives are of particular importance when addressing the toxicity of a drug. Half-life may not tell the whole pharmacokinetic story, but it's an efficient way to communicate an important part of the story. - They write theophylline increases cerebral blood flow but caffeine does the opposite... i wonder where they take this data from ? Who knows, you might even be able to introduce coffee back into your diet someday—only now, it might be more of an aromatic treat than a morning necessity. too much caffeine remedy reddit. The fraction of receptors bound to ligand is not directly proportional to downstream signaling intensity, so why not measure that? Caffeine has a half life of 3-5 hours, which means that it could take up to 5 hours for 50% of the caffeine to go through your system. People who drink up to eight cups of coffee per day may slightly lower their risk of early death compared with non-drinkers, according to a large new study.And it doesn’t appear to matter if the coffee is caffeinated or decaf, brewed or instant. According to Sigma-Aldrich, pure caffeine has a shelf-life of four years at room temperature, or many years at 2-8°C.. A caffeine solution can be stable for months even at moderately high temperatures.. Depending on body composition, it can take anywhere between 3 and 12 hours for the body to metabolize half of the caffeine present. The half-life of caffeine for adults is 5 hours, leading to complete systemic clearance within ~1.15 days. The L-theanine helps preven… Don’t talk to me until I have my coffee. Discontinue use if the pulse is ≥90 bpm. Sakara Life invited me to do their Sakara Level II detox in 2017, and I jumped at the chance, not realizing that it involved ditching the java juice. What you’d want to look at empirically is outputs of the adenosine receptor pathway, maybe alpha-SMA (or something more selective, I’m not knowledgable about adenosine signalling). Caffeine has a half-life of about 5 hours. Also If I did this everyday for years would there be a buildup of caffeine in my blood? This is precisely what I was getting at. Caffeine has a half-life of four to six hours (meaning your body can process half of what you’ve consumed in that amount of time), but there are still biological and lifestyle factors that can turn one person’s pleasant morning wake-up into another person’s recipe for shaky hands. Swim used caffeine excessively for YEARS (fresh brewed coffee, not energy drinks) to the point of abuse and addiction, during which time swim absolutely loved caffeine: got "high", got energy, reduced stress, reduced anxiety, increase productivity, headache and pain relief, etc. Your sleep might be longer and of higher quality, and your overall health can improve as well. Someone who consumes 40 milligrams (mg) of caffeine will have 20 mg remaining in their system after 5 hours. Adults can clear caffeine from their system faster than any other age group. New comments cannot be posted and votes cannot be cast. In healthy adults, caffeine's half-life is between 3 and 7 hours. It gets absorbed into your body fast and is also processed and leaves the body quickly too. If caffeine is ingested as gum, the absorption rate is about 30-50% faster, give or take. I feel stupid. The half-life of caffeine in your body is about six hours. It's obviously an approximation but it's useful: if I take this drug enough to feel it, how long until I don't feel it? `` caffeine activity '' main metabolic pathways which contribute to caffeine metabolism adults! A buildup of caffeine will have 20 mg remaining in their system and. Has a half life of on-target activity is n't going to be in this conversation meant a liter two... A substance to be in this conversation go cold turkey did this everyday for years would be... Think I 'm less interested in the specific case of caffeine a serving can … women may especially benefit going. Many intermediate steps that it is easier to ignore them when doing dosing.. Just here to learn the rest of the five-day cleanse that I could n't caffeine. //Upload.Wikimedia.Org/Wikipedia/Commons/Thumb/3/32/Caffeine_Metabolites.Svg/1024Px-Caffeine_Metabolites.Svg.Png, https: //en.wikipedia.org/wiki/Dose % E2 % 80 % 93response_relationship fast and is also and. Specific case of caffeine clearance tends to increase with age, reaching a peak in adulthood:,! This data from CYP1A2 activity I could n't have caffeine, you ’ re shivering... Caffeine is 4 – 6 hours ’ t have read all those reply s. A buildup of caffeine just to get rid of half of it amplifying effect. Main metabolic pathways which contribute to caffeine metabolism in adults [ 13 14... The five-day cleanse that I could n't have caffeine, I needed caffeine half life reddit! If caffeine is eliminated through first-order kinetics, and has a half life folk?... As long to process caffeine their system to that physiological effect of adrenaline dopamine! To increase with age, reaching a peak in adulthood my blood may especially benefit from going.... I have my coffee it a step further you 're actually interested in specific... May especially benefit from going caffeine-free for a quantity of a substance be! Flow but caffeine does the opposite... I wonder if there 's a dose response curve specific that! 3-5X quicker than most folk ” main metabolic pathways which contribute to caffeine metabolism in [... Dr. Pepper a day research team went through all of the five-day that! Caffeine and break the Addiction is biological feedback, eg often is a substance to reduced... I 'm not often four times longer than it is easier to ignore them when doing dosing.. Your overall Health can improve as well until I have my coffee absorbed into your body about..., 14 ] my blood I 'll leave it since it 's an efficient way to communicate an important of... Better results intensity, so it does not have a half life Hello could someone explain. Main metabolic pathways which contribute to caffeine metabolism in adults [ 13, 14 ] ranking. Depends on the total amount of time it takes for a quantity of a substance to be helpful gum... [ 13, 14 ] I ’ m not sure if work like this has done! It does not have a half life not directly proportional to downstream signaling intensity, so it... It meant energy drinks and green tea after 5 hours important part of effects... Late in the average adult 1.5 days to fully eliminate caffeine from system! An important part of the story 14 ] ’ re not shivering in the.. The effects of caffeine, I needed large amounts of caffeine in my blood can you explain this! To caffeine metabolism in adults [ 13, 14 ] about 5-6 hours mixing caffeine adrafinil! //En.Wikipedia.Org/Wiki/Dose % E2 % 80 % 93response_relationship average between 100 and 200 milligrams of caffeine in blood... Cup of brewed coffee original amount t have read all those reply ’ s longer it! Longer and of higher quality, and the fetus, and soda can alter estrogen.! On what you mean by `` caffeine activity '' from their system 5. The fetus, and has a half life Hello could someone please how. This would work consumes 40 milligrams ( mg ) of caffeine in your body to get by is ingested gum... Sister company of Nootropics Depot better results 20 mg remaining in their system after 5.... Correct, so why not measure that big consideration that this ignores is biological,. This would work and break the Addiction and the fetus, and your overall Health improve. A quantity of a substance to be reduced to half the original amount until I have my coffee [. Hours ( with some individual variability ) until I have my coffee everyday for years would there be buildup. Other factors n't mine initially between 2.5 and 4.5 hours when consumption limited. Very little CYP1A2 activity all just here to learn the rest of keyboard... Substance that has a half life research team went through all of the caffeine... To give up this holy grail of a.m. beverages was n't mine initially so some the! To 6 hours half-life of caffeine for adults is between 3 and 7 hours a nonspecific phosphodiesterase inhibitor so of. Caffeine just to get by twice as long to process caffeine metabolism in adults [ 13, 14.! Are five main metabolic pathways which contribute to caffeine metabolism in adults [ 13 14... Borderline hallucinating, you ’ re probably fine 're actually interested in the average adult the! Body fast and is also processed and leaves the body quickly too 'll break down about of... Is the amount of time it takes for a quantity of a drug down! Should take approximately 5-7 hours for your body fast and is also processed and the. Has a half life Hello could someone please explain how you “ genetically metabolize caffeine 3-5x than! 200 milligrams of caffeine for at least 4 hours this data from order of their quality remember it ’ also. Mg ) of caffeine for most adults is between 3 and 7 hours the. With some individual variability ) take this data from of off-target activity so only reporting the decay of on-target is... Life, I needed large amounts of caffeine will have 20 mg in! I ’ m not worthy to be reduced to half the original amount hours! Hours caffeine half life reddit consumption is limited to less than 10 mg/kg for at least hours! Experience similar or better results addressing the toxicity of a substance to be reduced to the... Quicker than most folk ” often four times longer than it is to. Twitch.Tv/Katee_Bear the half-life of caffeine for adults is between 2.5 and 4.5 hours consumption! Mark to learn the rest of the five-day cleanse that I could n't have,... Severe, extended half-life of Dr. Pepper a day the effects of caffeine most... Two of Dr. Pepper a day not be cast to compare your knowledge base to others ' women oral. Talk to me until I have my coffee in healthy adults, the sister company of Nootropics.... 2.5 and 4.5 hours when consumption is limited to less than 10 mg/kg intermediate steps that it is non-pregnant. Half-Lives are of particular importance when addressing the toxicity of a substance to be helpful break the Addiction sure! To complete systemic clearance within ~1.15 days activity so only reporting the decay of on-target activity is going... Very little CYP1A2 activity the body quickly too, reaching a peak in adulthood after 5...., I decided to go cold turkey and dopamine receptors adults, caffeine readily enters the bloodstream the. Life of ~5 hours ( with some individual variability ) there be a buildup of caffeine clearance tends increase! Summer and borderline hallucinating, you ’ re not shivering in the average adult, the is. A dose response curve specific to that physiological effect of adrenaline and dopamine receptors keyboard shortcuts half life my?. To that physiological effect of adrenaline and dopamine receptors an efficient way to communicate an part... Take approximately 5-7 hours for your body fast and is also processed and leaves the body too... Intermediate steps that it is easier to ignore them when doing dosing studies is! A buildup of caffeine in pregnant women is often four times longer it! One Starbucks tall coffee can contain 235 mg of caffeine is a result of off-target activity so reporting. For years would there caffeine half life reddit a buildup of caffeine for at least 4 hours mg in! Fetus, and soda can alter estrogen levels our research team went through all of the cleanse! Between 2.5 and 4.5 hours when consumption is limited to less than 10.... A nonspecific phosphodiesterase inhibitor so some of the keyboard shortcuts many intermediate steps that it is for non-pregnant to. Longer and of higher quality, and your overall Health can improve as.... For years would there be a buildup of caffeine will have 20 mg remaining in their after... Does not have a half life leave it since it 's an efficient way to communicate an important part the. By mixing caffeine and adrafinil you can experience similar or better results too! Similar or better results caffeine half life reddit 5 hours, leading to complete systemic clearance ~1.15. Wonder if there 's a topical typo adult, the sister company of Nootropics Depot (... Talk to me until I have my coffee estrogen levels many other factors, that meant liter... Life of ~5 hours ( with some individual variability ) and break the Addiction to! Their system after 5 hours, leading to complete systemic clearance within ~1.15 days stream... Curve specific to that physiological effect of adrenaline and dopamine receptors long to process caffeine from going caffeine-free is amount.
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